Fig. 4.

Both p-gp and bcrp contribute to the dexamethasone-induced increase in Ho342 efflux. Primary rat brain endothelial cells were cultured with 250 nM dexamethasone for 24 h. Before the drug accumulation assay was conducted, the endothelial cells were preincubated with 5 μM of the specific BCRP inhibitor fumitremorgin C (FTC) for 15 min and subsequently for the entire duration of the drug accumulation assay. **P < 0.01 vs. untreated cells, *P < 0.05 vs. dexamethasone-treated cells, #P < 0.05 vs. untreated cells.