Figure 1.

Paricalcitol reduces renal inflammatory T cell infiltration. (A through E) Immunohistochemical staining revealed an increased infiltration of CD3⁺ T cells in the obstructed kidney at 7 d (B) and 14 d (D), respectively, after UUO, compared with sham control (A). Paricalcitol treatment at 0.3 μg/kg body wt effectively inhibited the infiltration of T cells in the obstructed kidneys at 7 d (C) and 14 d (E) after UUO, respectively, as indicated. Bar = 20 μm. (F) Graphic presentation of quantitative data. Data are means ± SEM of five animals per group. *P < 0.01 versus sham control; †P < 0.01 versus vehicle.