Figure 2.

Paricalcitol inhibits renal inflammatory macrophage infiltration. (A through E) Immunohistochemical staining showed an increased infiltration of F4/80⁺ myeloid cells including macrophages and renal dendritic cells in the obstructed kidney at 7 d (B) and 14 d (D), respectively, after UUO, compared with sham control (A). Paricalcitol at 0.3 μg/kg body wt inhibited the infiltration of the F4/80⁺ cells in the obstructed kidneys at 7 d (C) and 14 d (E), respectively, after UUO as indicated. Bar = 20 μm. (F) Graphic presentation of quantitative data. Data are means ± SEM of five animals per group. *P < 0.01 versus sham control; †P < 0.01 versus vehicle.