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Effect of brivaracetam and levetiracetam against secondary generalized motor seizures
| Brivaracetam | Levetiracetam | |
|---|---|---|
| ED50 (mg kg−1 i.p.), corneally kindled mice (mean value and range) | 1.2 (0.6–2.4) | 7.3 (1.8–10.0) |
| MAD (mg kg−1 p.o.), hippocampal-kindled rats | 0.21 | 54 |
MAD, minimal active dose, the first dose inducing a significant reduction in seizure severity score vs predrug value (P<0.05).
