Figure 1.

Effect of the selective CB₁ receptor agonist ACEA and the selective CB₂ receptor agonist JWH-015 on λ-carrageenin (CAR)-induced granuloma. (a) ACEA (0.5, 5, 50 μg per implant) and JWH-015 (0.5, 5, 50 μg), significantly and in a concentration-dependent manner reduced granulomatous tissue formation, evaluated as wet weight at 96 h after implantation. (b) Local administration of ACEA (50 μg) or JWH-015 (50 μg) or the non-selective CB₁/CB₂ receptor agonist, WIN 55,212-2 (WIN; 50 μg), significantly reduced angiogenesis, evaluated as haemoglobin (Hb) content of the granuloma. No effects were observed in the group treated with vehicle (10% ethanol;EtOH). Results are expressed as mean±s.e.m. of three separate experiments. ^*P<0.05, ^***P<0.001 vs saline; °°P<0.01, °°°P<0.001 vs λ-carrageenin alone.