Figure 5.

Effect of the CB₁ receptor agonist ACEA (50 μg) and the CB₂ receptor agonist JWH-015 (50 μg) on angiogenesis in granulomatous tissue. Angiogenesis was evaluated by histological analysis and vessel number. Panel (a) shows a representative histological analysis of granulomatous tissue stained with hematoxylin and eosin. Fields are representative of three separate experiments. Original magnification × 100. Panel (b) shows the number of blood vessels in granulomatous tissue. Results are expressed as mean±s.e.m. of three separate experiments. ^*P<0.05, ^***P<0.001 vs saline; °°°P<0.001 vs λ-carrageenin (CAR) alone.