Skip to main content
. 2008 Sep;57(9):2413–2420. doi: 10.2337/db07-1323

FIG. 6.

FIG. 6.

HES1 shRNA reduces the decrease in insulin content and glucose-stimulated insulin secretion observed during dedifferentiation of cultured islet cells. A: Insulin content in cells infected with HES1 shRNA TRCN18993 or nontarget virus compared with primary islets. Data are means ± SD (n = 3 donors). Asterisks indicate statistical significance (P = 0.03). B: Insulin secretion in response to glucose during a 30-min assay. Data are means ± SD (n = 3 individual experiments from a representative donor). Asterisk indicate statistical significance of the difference between 0 and 16 mmol/l glucose in each cell type (P < 0.04). ▪, 0 mmol/l; □, 16 mmol/l.