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. Author manuscript; available in PMC: 2008 Aug 21.
Published in final edited form as: J Comb Chem. 2007 May 27;9(4):592–600. doi: 10.1021/cc070023a

Figure 3.

Figure 3

HeLa cell permeability, transcriptional activities of OxDex-TBHKs and binding affinity of carboxyfluorescein substituted TBHKs to GST-KIX (see Figure S3 for structures). (A) HeLa cell permeability of OxDex-TBHK1,5,6. OxDex-AEEA-CONH2 (×), OxDex-TBHK1(■), OxDex-TBHK5(●) or OxDex-TBHK6 (▲). (B) In vitro binding of carboxyfluorescein-substituted TBHKs to GST-KIX monitored by fluorescence polarization. Data processing is the same as that in Figure 1E. Each data point, shown as mean - SD, represents an average of three independent measurements. (C) Activation domain-like activity of OxDex-TBHK1,5,6. The symbol designations are the same as in (A). The data, shown as mean + SD, are representative of at least three independent experiments performed in duplicate. The curves are the best fit of the data to the sigmoidal dose-response model in Prism4.0.