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. Author manuscript; available in PMC: 2008 Aug 21.
Published in final edited form as: J Comb Chem. 2007 May 27;9(4):592–600. doi: 10.1021/cc070023a

Figure 4.

Figure 4

Structure and activity of ImPy7-TBHK6. (A) Structure of ImPy7-TBHK6 (see Scheme S1 for its synthesis). (B) Transcriptional activity of ImPy7-TBHK6 in HeLa cells. Reporter plasmids pGL3-6×HPB, pGL3-2×HPB, pGL3-E1b have six, two, and zero ImPy7 binding sites upstream of luciferase gene, respectively. The fold of induction represents the ratio of the inducible luciferase activity normalized to the constitutively expressed Renilla luciferase activity. The activities were measured after incubating the cells with the compound indicated for 40 hours.