Table 1.
List of nsSNPs that were predicted to be deleterious by SIFT and PolyPhen
| SNPs ID | Alleles | AA change | Tolerance index | PSIC |
|---|---|---|---|---|
| rs1800072 | G/A | V11C | 1.00 | 0.150 |
| rs1800073 | C/T | R31C | 0.18 | 2.288 |
| rs1800074 | A/T | D44V | 0.01 | 2.532 |
| rs1800076 | G/A | R75Q | 0.03 | 1.754 |
| rs1800078 | T/C | L138P | 0.01 | 2.192 |
| rs35516286 | T/C | I148T | 0.41 | 1.743 |
| rs1800079 | G/A | R170H | 0.05 | 1.968 |
| rs1800080 | A/G | S182G | 0.03 | 1.699 |
| rs1800086 | C/G | T351S | 0.30 | 1.600 |
| rs1800087 | A/C | Q353H | 0.03 | 2.093 |
| rs4727853 | C/A | N417K | 1.00 | 0.015 |
| rs11531593 | C/A | F433L | 0.65 | 0.694 |
| rs1800089 | C/T | L467F | 0.15 | 1.568 |
| rs213950 | G/A | V470M | 0.17 | 1.432 |
| rs1800092 | C/A/G | I506M | 0.00 | 1.574 |
| rs1801178 | A/G | I507V | 0.38 | 0.314 |
| rs1800093 | T/G | F508C | 0.00 | 3.031 |
| rs35032490 | A/G | K532E | 1.00 | 1.525 |
| rs1800097 | G/A | V562I | 0.13 | 0.345 |
| rs41290377 | G/C | G576A | 0.33 | 1.262 |
| rs766874 | C/T | S605F | 0.03 | 2.147 |
| rs1800099 | A/G | S654G | 0.03 | 1.611 |
| rs1800100 | C/T | R668C | 0.01 | 2.654 |
| rs1800101 | T/C | F693L | 0.61 | 0.895 |
| rs1800103 | A/G | I807M | 0.01 | 1.554 |
| rs1800106 | T/C | Y903H | 0.52 | 0.183 |
| rs1800107 | G/T | S909I | 0.10 | 1.624 |
| rs1800110 | T/C | L967S | 0.07 | 1.683 |
| rs1800111 | G/C | L997F | 0.24 | 1.000 |
| rs1800112 | T/C | I1027T | 0.03 | 1.860 |
| rs1800114 | C/T | A1067V | 0.04 | 1.542 |
| rs36210737 | T/A | M1101K | 0.05 | 2.637 |
| rs35813506 | G/A | R1102K | 0.52 | 1.589 |
| rs1800120 | G/T | R1162L | 0.00 | 2.038 |
| rs1800123 | C/T | T1220I | 0.22 | 0.059 |
| rs34911792 | T/G | S1235R | 0.45 | 1.483 |
| rs11971167 | G/A | D1270N | 0.12 | 1.739 |
| rs4148725 | C/T | R1453W | 0.00 | 2.513 |
Highly deleterious by SIFT and damaging by PolyPhen are indicated as bold