Table 1.

 Mean (SE) scores on health related quality of life as measured with women’s health questionnaire by treatment group

Component	Baseline			One year		Adjusted† difference at one year (95% CI)	P value
	Combined HRT (n=1043*)	Placebo (n=1087*)		Combined HRT (n=1043*)	Placebo (n=1087)*
Depression	0.803 (0.004)	0.797 (0.004)		0.803 (0.004)	0.805 (0.004)	0.00 (−0.01 to 0.01)	0.39
Somatic	0.755 (0.006)	0.764 (0.006)		0.775 (0.006)	0.781 (0.006)	0.00 (−0.02 to 0.01)	0.80
Memory	0.730 (0.010)	0.721 (0.009)		0.759 (0.009)	0.757 (0.009)	0.00 (−0.02 to 0.02)	0.88
Vasomotor	0.766 (0.012)	0.771 (0.011)		0.926 (0.007)	0.833 (0.010)	0.09 (0.07 to 0.12)	<0.001‡
Anxiety	0.882 (0.006)	0.882 (0.006)		0.894 (0.006)	0.904 (0.006)	0.00 (−0.02 to 0.00)	0.18
Sexual	0.679 (0.012)	0.679 (0.013)		0.764 (0.0110	0.721 (0.012)	0.05 (0.02 to 0.08)	<0.001‡
Sleep	0.637 (0.010)	0.657 (0.010)		0.740 (0.009)	0.703 (0.009)	0.05 (0.02 to 0.07)	<0.001‡
Menstrual	0.906 (0.005)	0.905 (0.005)		0.905 (0.005)	0.907 (0.005)	0.00 (−0.01 to 0.01)	0.77
Esteem	0.546 (0.004)	0.544 (0.004)		0.559 (0.004)	0.553 (0.004)	0.00 (−0.01 to 0.02)	0.40

*No in each group at each time point for any measure except sexual function (n=591 for cHRT group (588 at one year) and 580 for placebo group (569 at one year) for women who attended interview).

†Adjusted for baseline score.

‡Significant at Bonferroni corrected α level of 0.001; actual unadjusted P values presented.