Table 2.
Prevalence of symptoms related to menopause. Figures are numbers (percentages) of women
| Symptom | Baseline | One year | Adjusted† difference at one year (95% CI) | P value§ | |||
|---|---|---|---|---|---|---|---|
| Combined HRT (n=1041*) | Placebo (n=1085*) | Combined HRT (n=1043*) | Placebo (n=1087*) | ||||
| Hot flushes | 317 (30) | 311 (29) | 98 (9) | 269 (25) | −15 (−18 to −12) | <0.001‡ | |
| Night sweats | 283 (27) | 281 (26) | 145 (14) | 252 (23) | −9 (−13 to −6) | <0.001‡ | |
| Insomnia | 471 (45) | 472 (44) | 367 (35) | 450 (41) | −6 (−10 to −2) | <0.001‡ | |
| Feeling depressed | 195 (19) | 207 (19) | 234 (22) | 256 (24) | −1 (−5 to 2) | 0.6 | |
| Feeling anxious | 293 (28) | 284 (26) | 300 (29) | 313 (29) | 0 (−4 to 4) | 0.7 | |
| Dizziness | 117 (11) | 137 (13) | 133 (13) | 143 (13) | 0 (−3 to 2) | 1 | |
| Aching joints or muscles | 659 (63) | 680 (63) | 592 (57) | 688 (63) | −7 (−11 to −2) | <0.001‡ | |
| Tiredness | 523 (50) | 516 (48) | 556 (53) | 554 (51) | 2 (−2 to 7) | 0.5 | |
| Headache | 264 (25) | 288 (27) | 268 (26) | 273 (25) | 1 (−3 to 4) | 0.6 | |
| Migraine | 44 (4) | 56 (5) | 51 (5) | 60 (6) | −1 (−3 to 1) | 0.8 | |
| Irritability/mood swings | 181 (17) | 183 (17) | 186 (18) | 220 (20) | −2 (−6 to 1) | 0.1 | |
| Heart racing or skipping beats | 114 (11) | 112 (10) | 149 (14) | 128 (12) | 2 (0 to 5) | 0.1 | |
| Dry skin or scaling | 319 (31) | 332 (31) | 304 (29) | 326 (30) | −1 (−5 to 3) | 0.6 | |
| Vaginal or genital dryness | 249 (24) | 244 (22) | 150 (14) | 211 (19) | −5 (−8 to −2) | <0.001‡ | |
| Vaginal or genital itching | 115 (11) | 101 (9) | 121 (12) | 118 (11) | 1 (−2 to 3) | 0.9 | |
| Vaginal or genital discharge | 58 (6) | 48 (4) | 151 (14) | 55 (5) | 9 (7 to 12) | <0.001‡ | |
| Pain or burning while urinating | 31 (3) | 31 (3) | 36 (3) | 39 (4) | 0 (−2 to 1) | 0.8 | |
| Breast tenderness | 65 (6) | 69 (6) | 164 (16) | 76 (7) | 9 (6 to 11) | <0.001‡ | |
| Leg cramps in one leg | 96 (9) | 108 (10) | 122 (12) | 113 (10) | 1 (−1 to 4) | 0.3 | |
| Leg cramps in both legs | 169 (16) | 167 (15) | 227 (22) | 205 (19) | 3 (−1 to 6) | 0.1 | |
| Swelling in one leg | 45 (4) | 35 (3) | 44 (4) | 31 (3) | 1 (0 to 3) | 0.2 | |
| Swelling in both legs | 96 (9) | 80 (7) | 82 (8) | 98 (9) | −1 (−4 to 1) | 0.07 | |
| Nausea | 85 (8) | 87 (8) | 84 (8) | 91 (8) | 0 (−3 to 2) | 0.8 | |
| Abdominal cramps | 70 (7) | 76 (7) | 81 (8) | 95 (9) | −1 (−3 to 1) | 0.4 | |
| Bloating | 235 (23) | 217 (20) | 215 (21) | 260 (24) | −3 (−7 to 0) | 0.005 | |
| Skin rash/itching | 185 (18) | 166 (15) | 187 (18) | 177 (16) | 2 (−2 to 5) | 0.6 | |
| Crawling feelings under skin | 83 (8) | 81 (7) | 77 (7) | 76 (7) | 0 (−2 to 3) | 0.8 | |
| Trouble seeing not corrected by glasses/contact lenses | 46 (4) | 54 (5) | 51 (5) | 64 (6) | −1 (−3 to 1) | 0.4 | |
*No of women with available data.
†Adjusted for baseline presence of symptom.
‡Significant at Bonferroni corrected α level of 0.001; actual unadjusted P values presented.