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. 2008 Aug 25;182(4):741–752. doi: 10.1083/jcb.200804131

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© 2008 Mallo et al.

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Figure 9. — Model of SopB action in host cells during Salmonella infection. During invasion, S. typhimurium injects SopB into host cells. At the plasma membrane, SopB mediates dephosphorylation of PI(4,5)P₂ to generate PI(4/5)P. Through this event, SopB causes the accumulation of PI(3,4)P₂ and PI(3,4,5)P₃ at invasion ruffles by a wortmannin/LY294002-insensitive mechanism. SopB-mediated dephosphorylation of PI(4,5)P₂ also allows SCV fission from the plasma membrane and the recruitment of Rab5 to nascent SCVs via their fusion with early endosomes. The Rab5 effector Vps34 catalyzes phosphorylation of PI to generate PI(3)P on SCVs, leading to downstream SCV maturation events such as the recruitment of LAMP-1.