Table 3.
Cytotoxicity Data of Compounds 1, 1a–1h, 2, 2a, and 3–7
| cell line a,b | |||
|---|---|---|---|
| compound | Lu1 | LNCaP | MCF-7 |
| 1 | 1.0 | 0.5 | 0.2 |
| 1a | 2.6 | 1.1 | 1.5 |
| 1b | 3.4 | 1.9 | 1.3 |
| 1c | 4.0 | 3.0 | 3.2 |
| 1d | 22.2 | 17.9 | 14.6 |
| 1e | 10.3 | 5.1 | 4.7 |
| 1f | 12.8 | 5.8 | 4.8 |
| 1g | 1.3 | 0.8 | 0.7 |
| 1h | 30.5 | 22.1 | 7.5 |
| 2 | 3.1 | 1.2 | 1.9 |
| 2a | 5.7 | 2.2 | 3.5 |
| 3 | 1.8 | 1.8 | 0.5 |
| 4 | 1.0 | 0.7 | 0.5 |
| 5 | 1.8 | 4.4 | 3.9 |
| 6 | 0.9 | 0.7 | 0.9 |
| 7 | 0.5 | 0.9 | 0.7 |
a
Results are expressed as ED50 values (µM), and values < 10 µM are considered to be active.
b
Key to cell lines used: Lu1 (human lung carcinoma); LNCaP (hormone-dependent human prostate carcinoma); MCF-7 (human breast carcinoma).