Table 1.
Genes regulated by SKA2 knockdown involved in cell cycle, apoptosis and signalling (SKA2 result included). Genes found to be significantly up- or downregulated in response to ‘knockdown’ of SKA2 expression by specific siRNA. Statistical significance is indicated by q value
| Entrez gene | Probe set ID | Fold change | q value | Gene title | |
|---|---|---|---|---|---|
| Gene symbol | |||||
| Downregulated | |||||
| SKA2 | 348 235 | 225684_at | −8·7 | 0·044 | Family with sequence similarity 33, member A |
| ABCA1 | 19 | 203504_s_at | −2·9 | 0·033 | ATP-binding cassette, sub-family A (ABC1), member 1 |
| PPP2R1B | 5519 | 202883_s_at | −2·6 | 0·110 | Protein phosphatase 2 (formerly 2A), regulatory subunit A, β isoform |
| CCL2 | 6347 | 216598_s_at | −2·5 | 0·143 | Chemokine (C-C motif) ligand 2 |
| IL6ST | 3572 | 204863_s_at | −2·2 | 0·110 | Interleukin 6 signal transducer (gp130, oncostatin M receptor) |
| PPP2CA | 5515 | 238719_at | −2·1 | 0·148 | Protein phosphatase 2 (formerly 2A), catalytic subunit, α isoform |
| BMP2K | 55 589 | 226853_at | −2·0 | 0·090 | BMP2 inducible kinase |
| EMR1 | 2015 | 207111_at | −2·0 | 0·185 | EGF-like module containing, mucin-like, hormone receptor-like 1 |
| SOCS3 | 9021 | 227697_at | −1·9 | 0·198 | Suppressor of cytokine signalling 3 |
| LRP12 | 29 967 | 220254_at | −1·9 | 0·143 | Low density lipoprotein-related protein 12 |
| RGS17 | 26 575 | 220334_at | −1·9 | 0·110 | Regulator of G-protein signalling 17 |
| WWTR1 | 25 937 | 202132_at | −1·6 | 0·159 | WW domain containing transcription regulator 1 |
| WWTR1 | 25 937 | 202133_at | −1·5 | 0·166 | WW domain containing transcription regulator 1 |
| Upregulated | |||||
| NOVA1 | 4857 | 205794_s_at | 1·5 | 0·185 | Neuro-oncological ventral antigen 1 |
| COL4A4 | 1286 | 214602_at | 1·6 | 0·159 | Collagen, type IV, α 4 |
| UNC5D | 137 970 | 231325_at | 1·7 | 0·169 | Unc-5 homolog D (C. elegans) |
| IGFBPL1 | 347 252 | 227760_at | 1·8 | 0·193 | IGF-binding protein-like 1 |
| GRB10 | 2887 | 209409_at | 1·8 | 0·169 | Growth factor receptor-bound protein 10 |
| G3BP2 | 9908 | 208841_s_at | 1·8 | 0·159 | GTPase activating protein (SH3 domain) binding protein 2 |
| PHACTR2 | 9749 | 227947_at | 1·8 | 0·159 | Phosphatase and actin regulator 2 |
| AI831506 (Refseq) | – | 226520_at | 2·0 | 0·091 | Primary neuroblastoma cDNA, clone:Nbla11485 |
| NOLC1 | 9221 | 211951_at | 2·2 | 0·088 | Nucleolar and coiled-body phosphoprotein 1 |
| CASP7 | 840 | 207181_s_at | 2·5 | 0·159 | Caspase 7, apoptosis-related cysteine peptidase |
| MESDC2 | 23 184 | 224675_at | 4·2 | 0·021 | Mesoderm development candidate 2 |