Table 4.
Pathologic findings in immune complex GN and atypical glomerulopathies in lupus recipients
| Case no. | Immunofluorescence |
Electron microscopy |
Other pathology | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| IgG | IgA | IgM | C3 | C1q | Fibrin | Glomerular location | PTC C4d | Electron dense deposits | TRI | ||
| Mesangial | |||||||||||
| 1 | 1 | 1 | 1 | NA | NA | 0 | m | NA | m | + | Old infarct |
| 2 | NA | NA | NA | NA | NA | NA | NA | NA | m | + | Diffuse IF and TA |
| 3 | 1 | 0.5 | 0.5 | 1 | 1 | 0 | m | − | m, sendo | + | Polyoma virus nephropathy |
| 4 | 1.5 | 1 | 1 | 0 | 0 | 0 | m | − | m | + | — |
| 5 | 2 | 0 | 0 | 0.5 | 0 | 0 | m | − | NA | NA | Focal IF and TA |
| 6 | 1 | 1 | 0 | 0 | 0 | 0 | m | − | 0 | + | Polyoma virus nephropathy |
| 7 | 1 | 1 | 0 | 0 | 0 | 0 | m | − | 0 | + | Acute rejection, type 1B |
| Membranous GN | |||||||||||
| 8 | 2 | 0 | 0 | 2 | 2 | 0 | cw | − | sepi, IM | + | Diffuse IF and TA |
| Acute proliferative GN | |||||||||||
| 9 | 0 | 0 | 0.5 | 0 | NA | 0 | cw, m | NA | 0 | + | Borderline infiltrate |
| 10 | 0 | 0 | 1 | 1 | 0 | 0 | cw, m | − | NA | NA | Borderline infiltrate, TMA |
| 11 | 0 | 0 | 0 | 0 | NA | 0 | − | − | 0 | 0 | Acute rejection, type 1B |
| 12 | 1 | 0 | 0.5 | 0 | 0 | 0 | cw, m | − | m, sendo | 0 | TMA |
| 13 | 1.5 | 0 | 1 | 1 | 1 | 2 | cw, m | − | sepi | + | — |
| 14 | 0.5 | 1 | 2 | NA | NA | 2 | cw, m | − | m, sendo | + | Borderline infiltrate, TMA |
| 15 | 1 | 0 | 0.5 | 0 | NA | 0 | cw, m | − | m, sendo, sepi | + | Arteriosclerosis |
| 16 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | TMA |
| Focal segmental glomerulosclerosis | |||||||||||
| 17 | 0 | 0 | 0.5 | 0 | 0 | 0 | cw | − | 0 | + | ATN |
| 18 | 0 | 0 | 1 | NA | NA | 0 | m | NA | 0 | + | TMA, ATN |
| 19 | 2 | 0 | 2 | 1.5 | 1.5 | 0 | m | − | 0 | + | TMA, ATN |
GN, glomerulonephritis; PTC, peritubular capillary; TRI, tubuloreticular inclusions; m, mesangial, cw, capillary wall; sendo, subendothelial; sepi, subepithelial; IF, interstitial fibrosis; TA, tubular atrophy; TMA, thrombotic microangiopathy; ATN, acute tubular necrosis; NA, not applicable.