Table 1.
Clinical and laboratory data at presentationa
| Parameter | Patients |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |
| Age (yr) | 75 | 74 | 65 | 68 | 68 | 55 | 74 | 67 | 62 | 69 | 63 | 66 | 69 | 72 |
| Gender | M | M | M | M | M | M | F | F | M | M | M | M | M | F |
| Creatinine level (μmol/L) | 152 | 135 | 245 | 77 | 123 | 278 | 466 | 173 | 450 | 203 | 179 | 187 | 115 | 557 |
| GFR (ml/min) | 39 | 44 | 21 | 87 | 40 | 20 | 8 | 25 | 11 | 38 | 45 | 48 | 55 | 12 |
| Hypertension | No | No | No | Yes | No | No | No | Yes | Yes | No | No | Yes | No | Yes |
| Proteinuria (g/d) | 0.35 | 0.38 | 0.72 | 16.00 | 6.00 | 4.60 | 8.00 | 4.50 | 1.30 | 1.34 | 2.00 | 6.00 | 5.50 | 0.41 |
| Serum albumin (g/L) | 42 | 39 | 36 | 18 | 19 | 27 | 26 | 17 | 38 | 47 | 35 | 26.5 | 20 | 43 |
| Hematuria (/ml) | No | No | 5 × 105 | No | No | No | 5 × 104 | 2.105 | 4 × 104 | No | 1.2 × 105 | 5 × 105 | 4 × 105 | No |
| Serum immuno-electrophoresis (g/L) | IgMλ (18.0) | IgMλ (10.8) | IgMκ (27.0) | IgMλ (28.4) | IgMλ (7.4) | IgMλ (7.1) IgAκ (2.0) | IgMλ (15.0) | IgMκ (7.0) | IgMκ (10.0) | IgMκ (4.0) | IgMκ (10.0) | IgMκ (5.0) | IgMκ (6.7) | IgMλ (6.7) |
| Urine immuno-electrophoresis | Free λ | Free λ | Free k | Free λ | Free λ | Free λ | Free λ | Free κ | Free κ | Free κ | Free κ | Free κ | Free κ | Free λ |
| C3 levels (g/L) | NL | NL | NL | NL | NL | NL | 0.55 | 0.45 | 0.55 | NL | NL | NL | NL | NL |
| C4 levels (g/L) | NL | NL | NL | NL | NL | NL | 0.02 | 0.07 | 0.07 | NL | NL | NL | NL | NL |
| CH50 levels (U/ml) | NL | NL | NL | NL | NL | NL | 10 | 12 | 10 | NL | NL | NL | NL | NL |
| Cryoglo-bulinemia | No | No | No | No | No | No | No | No | Yes | No | No | No | No | No |
| Hematologic disease | WM | WM | WM | Small B cell non-Hodgkin lymphoma | MM | IgMRD | WM | WM | WM | Splenic marginal zone B cell lymphoma | WM | Small B cell non-Hodgkin lymphoma | IgM RD | IgM RD |
| Kidney disease | LI | LI | LI | AL-A | AHL-A | ICMDD | ICMDD | ICMDD | ICMDD | ICMDD | MPGN | MPGN | MPGN | ATN |
| Kidney size (cm) | 13.513 | 1211 | 11.512 | 11.512 | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Normal | Normal |
a
AHL-A, AHL amyloidosis; AL-A, AL amyloidosis; ATN, acute tubular necrosis; ICMDD, intracapillary monoclonal deposits disease; IgM RD: IgM-related disorder; LI, lymphomatous infiltration; MM, multiple myeloma; MPGN, membranoproliferative glomerulonephritis; NL, normal level; WM, Waldenström macroglobulinaemia.