Figure 5. At the same shear rate, tensile force applied to bonds that link flowing platelets or microspheres is much lower than that applied to bonds that tether rolling platelets or microspheres.

(A) Platelets or GPIbα-bearing microspheres of 1-μm radius were perfused through a flow chamber containing immobilized vWF or WT A1. The rolling velocity is plotted versus the wall shear rate. Data are mean ± SD of 5 experiments. (B) Schematic showing tensile forces (F_t) between spheres of equal and unequal size in a doublet as well as between a sphere and the wall under a simple shear field.