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Typical SRM chromatograms obtained upon analysis of liver DNA from (A) control rats; (B) (R)-NNN-treated rats; and (C) (S)-NNN-treated rats after 10 weeks of treatment. Individual POB-DNA adducts or internal standards were monitored as indicated on each channel. In Figure 5A, the peak eluting at the position of O2-POB-dThd, the area of which is 0.2 % of [pyridine-D4]O2 -POB-dThd, originates from the internal standard.
