Figure 1.
Sequence comparison of GCS1. (A) Domain structure of Gcs1p. (B) Comparison of the CxxCx16CxxC amino-terminal zinc-binding domain of GCS1 to rat brain centaurin α, the yeast proteins GLO3, GTS1, and SPS18, and the rat liver Arf GAP. (C) Comparison of Gcs1p with merlin and the ERM family of proteins: ezrin, radixin, and moesin. (D) Comparison of the PH domain from GCS1 to six yeast proteins that contain PH domains according to the Stanford Saccharomyces Genome Database (SGD): NUM1, BEM2, OSH1, BUD4, BEM3, and BOB1. Shaded amino acids represent conserved amino acids in a majority of the family members; capital letters are amino acids conserved between GCS1 and other proteins. Conserved amino acids belong to the same Dayhoff group (GPAST, MILV, KRH, NQED, FWY, C).