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. 2008 Aug 1;9:76. doi: 10.1186/1471-2202-9-76

Figure 3.

Figure 3

Neuronal degeneration in brain. (A) Paraffin sections were stained with a neuron marker, NeuN, and a Purkinje cell marker, Calbindin D28K (calbindin). Progressive decreases in NeuN stained cells (upper panel) and incremental loss of Purkinje cells (lower panel) were shown in PS-NA mice at 12 wk and older. The NeuN changes were generalized, but regional variations in neuronal loss also were evident. (B) H&E stained paraffin sections of cerebellum showed the presence of Purkinje cells (arrows) in PS-/- (25 day) and WT (18 wk) mice and loss of Purkinje cells in PS-NA (18 wk) and 4L/PS-NA (18 wk) mice.