TABLE 2.

Detailed Adverse Events Data From the 9 Randomized Clinical Controlled Trials That Targeted the Pediatric Population Specifically

Indication	Reference	n	Age Range	Total Treatments	Therapy	No. Adverse Events	Description of Adverse Events
Chemotherapy-induced nausea and vomiting	Reindl et al15	11	6–18	11	Acupuncture	1	Needle pain
		11		NA	No acupuncture	0
Postoperative induced nausea and vomiting	Butkovic et al20	40	5–14	40	Laser acupuncture at P6 with saline IV	0	None reported
		40		40	Metaclopramide IV and sham laser	0	None reported
		40		40	Sham laser and saline infusion	0	None reported
Postoperative induced nausea and vomiting	Wang and Kain21	50	7–16	50	Acupuncture at P6 with saline IV	0	None reported
		49		49	Droperidol IV with sham acupuncture	0	None reported
		45		45	Saline IV with sham acupuncture	0	None reported
		43		43	Saline IV with sham point injections	0	None reported
Postoperative induced nausea and vomiting	Rusy et al22	40	4–18	40	Electroacupuncture	0	None reported
		40		40	Sham electroacupuncture	0	None reported
		40		NA	No acupuncture	0	None reported
Postoperative induced nausea and vomiting	Somri et al23	30	4–12	30	Acupuncture	1	Unscheduled overnight hospital admission
		30		NA	IV ondansetron	NA	1 patient required Unscheduled overnight hospital admission
		30		NA	IV saline	NA	2 patients stayed in the hospital over night and 1 readmitted to the hospital
Postoperative induced nausea and vomiting	Shenkman et al24	47	2–12	47	Acupressure/acupuncture	10	Puncture redness/irritation
		53		53	Sham acupressure/acupuncture	8	8 puncture Redness
Postoperative induced vomiting	Schlager et al25	20	3–12	40	Laser acupuncture	0	None reported
		20		40	Sham laser acupuncture	0	None reported
Seasonal allergic rhinitis	Ng et al27	32	6≤	512	Acupuncture	3	Numbness at acupuncture site
						1	Headache
						1	Light headedness
		31		496	Sham acupuncture	2	Numbness at acupuncture site
						2	Light headedness
Nocturnal enuresis	Radmayr et al36	20	5–16	249	Laser acupuncture	0	No side effects
		20		0	Desmopressin alone	0	No side effects
Total acupuncture/Sham Acupuncture Related				1865.00		29.00

A total of 782 patients were treated with ages ranging from 2–18 years. IV indicates intravenous; NA, not available.