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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Cancer Res. 2008 Jun 1;68(11):4068–4076. doi: 10.1158/0008-5472.CAN-07-5667

Figure 5. Postnatal RB ablation results in aberrant cell cycle progression after injury.

Figure 5

Immunohistochemical analysis for BrdU incorporation (A), and PH3 (B) and Ki67 (C) expression on day 14 after injury in RB ablated and control adult lungs from mice treated with doxycycline as adults. Percent positive cells (arrows) were quantified and data represented as average percent positive cells + SEM (D). RB ablated lungs showed a statistically significant increase in S-phase cells (BrdU), mitotic cells (PH3) and overall proliferation (Ki67) as compared to controls (*p=0.03, *p=0.04 and *p=0.004, respectively). Data is representative of 5–6 animals per time point. br=bronchiole; Original magnification: 1000×