Table 4.

Pd(OAc)₂-Catalyzed Domino Carbopalladation-Cross-coupling of Internal Alkynes and Hindered Grignard Reagents ^a

entry				yield(%)b
1				71
2				65
3				72
4				69
5				60
6				81
7				78
8				74
9				81

^aReaction conditions: alkyne (1.0 equiv), Grignard reagent (4.0 equiv), 1,2-dibromoethane (1.5 equiv), Pd(OAc)₂ (5%), PPh₃ (20%), THF (2 mL), refluxing, 30–40 h.

^bIsolated yields.