Table 2.

Levels of Acr-dGuo detected in human lung DNA.

					urinary biomarkers			Acr-dGuo levelc (adducts/109 nucleotides)
subject	gender	race	age at surgery	self-reported smoking historya	cotinine (ng/ml)	nicotine (ng/ml)	amount of DNA analyzed (mg)b	α-OH	γ-OH	total
1	F	W	60	current	652	115	0.14	91	47	138
2	F	W	47	current	5084	1462	0.51	45	21	66
3	F	W	52	2 yr	6.8	1.3	1.25	18	9	27
4	M	W	69	2 yr	25.2	4.5	1.09	18	10	27
5	F	W	72	10 yr	3.7	0.7	0.20	25	49	74
6	F	W	79	10 yr	9.2	1.3	0.10	78	49	127
7	M	W	66	26 yr	4.3	1.5	0.03	154	55	209
8	F	W	51	3 months	2397	534	0.70	10	6	16
9	M	W	53	current	2346	410	0.81	15	10	25
10	M	W	53	current	692	117	0.54	ND	159	159
11	F	W	61	9 yr	26.7	4.1	0.29	75	47	121
12	F	B	52	6 yr	34.1	16.4	0.55	25	12	36
13	F	W	37	current	3.3	1.7	0.61	16	9	25
14	M	W	78	24 yr	7.2	0.6	0.09	85	53	138
15	F	W	68	1 month	NA	NA	0.65	33	23	56
16	F	W	72	2 months	NA	NA	0.49	20	13	33
17	M	W	78	NA	NA	NA	0.77	12	18	29
18	F	W	60	2 yr	NA	NA	0.10	44	24	68
19	M	W	72	7 yr	NA	NA	0.86	10	6	16
20	F	W	46	1 week	NA	NA	0.72	10	9	19
21	F	W	81	23 yr	NA	NA	0.48	17	17	34
22	F	W	58	18 yr	NA	NA	1.08	13	13	26
23	F	W	76	10 yr	NA	NA	0.04	110	82	192
24	M	W	66	17 yr	NA	NA	0.64	16	14	29
25	F	W	51	1 yr	NA	NA	0.53	10	13	24
26	F	W	56	1 yr	NA	NA	0.33	35	21	56
27	M	W	74	16 yr	NA	NA	0.79	15	11	26
28	M	W	69	9 yr	NA	NA	0.84	20	22	42
29	F	W	49	2 months	NA	NA	0.98	17	12	29
30	NAe	NA	NA	NA	NA	NA	0.04	111	47	158
Mean ± S.D.			62.2 ± 12				0.54 ± 0.35	40 ± 38	29 ± 31	68 ± 58

^aReported time since quitting

^bCalculated based on dGuo

^cEach value represents a single measurement. dGuo was determined by HPLC-UV.

^dND, not detected

^eNA not available