Table 1.
Retrovirus Receptors
| Retrovirus | Receptor | Type a | Function |
|---|---|---|---|
| Human immunodeficiency virus, simian immunodeficiency virus | CD4 and
CXCR4, CCR5, others |
TM1
TM7 |
Immune function
G protein-coupled chemokine receptors |
| Feline immunodeficiency virus | CD134 and
CXCR4 |
TM1
TM7 |
Immune function
G protein-coupled chemokine receptor |
| Human T-cell leukemia virus | GLUT-1 | TM12 | Glucose transporter |
| Ecotropic murine leukemia virus | CAT-1 (SLC7A1) | TM14 | Basic amino acid transport |
| Gibbon ape leukemia virus, amphotropic murine leukemia virus, 10A1 murine leukemia virus, feline leukemia virus type B, woolly monkey virus | Pit1 (SLC20A1) or Pit2 (SLC20A2) | TM10–13 | Phosphate transport |
| RD114, type D simian retroviruses, baboon endogenous virus, human endogenous retrovirus type W | RDR (SLC1A5) or
RDR2 (SLC1A4) |
TM9–10
TM9–10 |
Neutral amino acid transport
Glutamate and neutral amino acid transport |
| Xenotropic and polytropic murine leukemia viruses | XPR1 | TM8 | G protein-coupled signaling? Transport? |
| Feline leukemia virus type A | Thtr1 | TM12 | Thiamine transport |
| Feline leukemia virus type C | Flvcr | TM12 | Heme export |
| Feline leukemia virus type T | Felix and
Pit1 (SLC20A1) |
soluble
TM10–13 |
Env-like protein
Phosphate transport |
| Pig endogenous retrovirus type A | Par-1 (GPR172A) or Par-2 (GPR172B) | TM10–11 | G protein-coupled receptors |
| M813 murine leukemia virus | Smit1 (SLC5A3) | TM14 | myo-inositol transport |
| Avian leukosis virus type A | Tva | TM1 | LDL receptor-like protein |
| Avian leukosis virus types B, D, E | Tvb | TM1 | Fas/TNFR-like receptor |
| Avian leukosis virus type C | Tvc | TM1 | Butyrophilin-like (immunoglobulin superfamily) |
| Avian leukosis virus type J | NHE1 (SLC9A1) | TM12 | Na+/H+ antiporter |
| Mouse mammary tumor virus | Tfr1 | TM1 | Transferrin receptor |
| Jaagsiekte sheep retrovirus, Enzootic nasal tumor virus | HYAL2 | GPI-anchored | Hyaluronidase (weak) |
a
TM indicates a transmembrane protein and the number after TM indicates the number of times the protein is predicted to span the membrane. GPI-anchored indicates a glycosylphosphatidylinositol-anchored membrane protein.