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. Author manuscript; available in PMC: 2008 Aug 23.

Published in final edited form as: Biochemistry. 2006 Jan 10;45(1):94–101. doi: 10.1021/bi052015l

Table 1.

A summary of the relative catalytic efficiencies (k_cat/K_m) of various Sir2 homologs with ten peptide substrates.

	Relative k_cat/K_m
Peptide	SIRT1	SIRT2	ySir2	TbSir2
AcGG(AcK)AP	1.7 ± 0.5	0.6 ± 0.1	1.5 ± 0.7	1.3 ± 0.2
AcTGG(AcK)AP	0.5 ± 0.1	0.6 ± 0.1	1.6 ± 0.6	0.7 ± 0.2
AcSTGG(AcK)AP	1.6 ± 0.5	0.8 ± 0.1	1.8 ± 0.8	0.6 ± 0.1
AcGG(AcK)APR	0.7 ± 0.1	0.6 ± 0.1	2.5 ± 1.3	1.2 ± 0.2
AcTGG(AcK)APR	0.6 ± 0.1	0.7 ± 0.1	1.7 ± 0.8	0.9 ± 0.2
AcSTGG(AcK)APR	0.7 ± 0.1	0.9 ± 0.2	1.6 ± 0.8	1.4 ± 0.2
AcGG(AcK)APRK	1.0 ± 0.2	0.7 ± 0.1	2.3 ± 0.9	1.8 ± 0.2
AcGG(AcK)APRKQ	0.8 ± 0.2	0.7 ± 0.1	2.1 ± 0.8	1.4 ± 0.2
AcKSTGG(AcK)AP	0.7 ± 0.1	0.6 ± 0.1	2.1 ± 0.8	1.8 ± 0.7
AcTGG(AcK)APRK	1.0 ± 0.1	1.0 ± 0.1	1.0 ± 0.4	1.0 ± 0.1