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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Chem Biol Drug Des. 2008 Jun 11;72(1):27–33. doi: 10.1111/j.1747-0285.2008.00676.x

Figure 1.

Figure 1

The effect of mutation and cyclization method on the activity of cIBR derivatives in inhibiting ICAM-1/LFA-1-mediated T-cell adhesion to Caco-2 cell monolayers in concentration-dependent manner. Mutation of Pen1 to Cys1 (cIBR-1) does not affect the activity and replacing L-Arg-3 with D-Arg-3 improves the activity of the peptide (cIBR-2). Amide bond cyclization via the side chains in cIBR-3 enhances the activity of the peptide.