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Effects of external KCl elevation on Ca2+ concentrations in cytosol ([Ca]cyt, A), microdomains ([Ca]md, B), and SR ([Ca]SR, C) as a function of time (in s). For clarity of presentation, [K]out is raised from 5.4 to 100 mM at t = 100 s for the common-store model and at t = 120 s for the separate-store model. D: signaling pathway after external KCl elevation.
