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. 2008 Jun 18;295(2):F605–F617. doi: 10.1152/ajprenal.90268.2008

Fig. 4.

Fig. 4.

12/15-LO siRNA administration reduces glomerular hypertrophy and mesangial matrix expansion in diabetic mice. A: representative photographs of periodic acid-Schiff (PAS)-stained kidney sections from nondiabetic mice with vehicle (a and e), diabetic mice treated with vehicle (b and f), siRNAs (c and g), or MM oligos (d and h). Quantitative measurements of glomerular area and mesangial matrix index, i.e., PAS-positive mesangial matrix area per total glomerular tuft cross-sectional area, are shown in B and C. A significant decrease in mesangial matrix fraction and glomerular area were observed in siRNA-injected mice relative to control groups. Values are means ± SE. *P < 0.05. #P < 0.01. $P < 0.001.