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Effect of pharmacological inhibition of c-Src on total (top) and active (bottom) TGF-β1 was determined using PP2, administered in the medium following harvest of tissues from rats on either 0.3 or 8.0% NaCl for 4 days (n = 12 rats in each group). Addition of PP2 inhibited production of both total and active TGF-β1. *P < 0.05 compared with untreated tissues from rats on the same diet. †P < 0.05 compared with untreated tissues from rats on the 8.0% NaCl diet.
