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. 2008 Jun 13;295(2):H743–H754. doi: 10.1152/ajpheart.00151.2008

Fig. 1.

Fig. 1.

Cardiovascular effects of nitrite in nonhemolyzing animals. A: serial plasma nitrite levels (in μM) in nonhemolyzing animals. In animals receiving a 6-h infusion of 5% dextrose (D5W), a sodium nitrite infusion of 27.5 mg/h (○) led to a rapid rise and then a sustained plasma nitrite concentration (range: 15–21 μM) compared with a placebo infusion of 0.9% NaCl (•). B–H: in nonhemolyzing animals, sodium nitrite increased the cardiac index (CI; B) and decreased the systemic vascular resistance index (SVRI; C), pulmonary vascular resistance (PVRI; D), mean arterial pressure (MAP; E), mean pulmonary arterial pressure (PAM; F), central venous pressure (CVP; G), and pulmonary artery occlusion pressure (PAOP; H) compared with placebo. Intravenous nitrite enhanced cardiac performance (CI) by arterial vasodilation (SVRI, PVRI, MAP, and PAM) and caused venodilation (CVP).