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. 2008 Jun 20;295(2):H807–H815. doi: 10.1152/ajpheart.00259.2008

Fig. 5.

Fig. 5.

Effect of baclofen on GABAergic spontaneous inhibitory postsynaptic currents (sIPSCs) in labeled PVN neurons in WKY rats and SHR. A: original tracings showing sIPSCs during control, bath application of 5, 10, and 20 μM baclofen, washout, and application of 10 μM bicuculline in a labeled PVN neuron in SHR. B and C: cumulative plot analysis of sIPSCs of the same neuron showing the distribution of the interevent interval (B) and amplitude (C) during control and application of baclofen. D and E: dose-response effect of baclofen on the frequency (D) and amplitude (E) of sIPSCs in labeled PVN neurons of WKY rats and SHR. F: summary data showing the percentage of baclofen-induced reduction of frequency in sIPSCs in WKY rats and SHR. G: summary data showing the effects of bath application of 2 μM CGP on the basal frequency of sIPSCs in WKY rats and SHR. Data are means ± SE. *P < 0.05 compared with control. #P < 0.05 compared with the corresponding value in WKY rats.