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Effects of lead on blood coagulation
| Effect of Lead | Effect on Coagulation |
|---|---|
| Endothelial injury | Facilitation of coagulation via contact with subendothelial tissue |
| Reduced NO availability | Heightening of platelet adhesion |
| Reduced t-PA and increased PAI-1 production | Inhibition of fibrinolysis |
NO, nitric oxide; t-PA, tissue plasminogen activator; PAI-1, plasminogen activator inhibitor-1.
