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A: treatment with soluble RAGE (sRAGE) to neutralize RAGE signaling partially restored ACh-induced vasodilation in diabetic mice (n = 6) but did not affect the vasodilation in control mice (n = 5). B: NAD(P)H oxidase activity was higher in diabetic mice, but sRAGE or nuclear factor-κB (NF-κB) inhibitor MG132 decreased NAD(P)H oxidase activity in diabetic vs. control mice (n = 6). *P < 0.05 vs. control, #P < 0.05 vs. diabetic.
