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. Author manuscript; available in PMC: 2008 Aug 25.
Published in final edited form as: J Org Chem. 2006 Dec 22;71(26):9561–9571. doi: 10.1021/jo0614240

Figure 3.

Figure 3

The post-translational maturation process of nisin as an example of a class I lantibiotic. The prepeptide NisA is ribosomally synthesized, followed by NisB catalyzed dehydration of underlined Ser and Thr residues of NisA. NisC catalyzes the conjugate addition of Cys residues in a regio- and stereoselective manner to five of the Dha (green) and Dhb (magenta) residues to generate five cyclic thioethers: one lanthionine (red) and four methyllanthionines (blue). After dehydration/cyclization is complete, the unmodified leader peptide is proteolytically removed by the protease NisP. The sequence of the leader peptide is MSTKDFNLDLVSVSKKDSGASPR. Abu, S-2-aminobutyric acid.