FIG. 1.

Relationship between ELISA anti-MSP1-19 titer and the degree of parasite growth inhibition of anti-MSP1-19 antibodies induced by different adjuvant formulations in WT, IL-6 KO, CD80 KO, CD86 KO, and ICAM-1 KO mice. Data are segregated into two groups represented by filled circles and open circles having parasite growth inhibition of >50% and <50%, respectively. Antibodies induced by the adjuvants ISA720-MPL, ISA720-QS21-MPL, and MPL-SE (filled circles) and antibodies induced by the adjuvants ISA720, MF59, QS21, ISA720-QS21, and MPL-AF (open circles) are shown. Regression lines (solid lines) for each of the two groups of data are shown with 95% confidence limits (dashed lines). A regression line (dotted pattern) for the entire combined data set is also shown.