FIG. 7.

DNase I inhibits biofilm formation at early stages of development. V583 biofilms grown on glass coverslips were treated with DNase I after 6, 12, and 24 h of growth (represented in panels B, C, and D, respectively) and analyzed after 26 h by CLSM. The biofilm micrograph on the far left (panel A) shows a control experiment with heat-inactivated DNase I introduced after 6 h of biofilm development. Below each panel is the z-projection for the corresponding image, indicating the depth of the biofilm. The inset scale bar represents 20 μm.