FIG. 3.

Linkage analysis and interval mapping reveals a single significant QTL on chromosome 17. (A) Ninety-five F₂ (CB6/F1J × CB6/F1J) mice were infected with 3,500 CFU of Y. pestis KIM5, and 48 h postinfection total splenic CFU was determined. LRS scores were generated using Map Manager QTX at 58 microsatellite markers across the genome. Based on the Map Manager QTX permutation test (1-cM intervals), the threshold for significance (P < 0.05) is an LRS score greater than 11.2. The CFU counts of all 95 mice based on their genotypes at the two suggestive loci on chromosomes 2 (B) and 12 (C), as well as a single significant locus on chromosome 17 (D), are shown.