TABLE 1.
Frequency of observed pathology of Y. pestis-infected mice
| Pathology | Frequency (no. of mice positive/no. of mice scored) in mice sacrificed at:a
|
|||
|---|---|---|---|---|
| C57BL/6J
|
BALB/cJ
|
|||
| 24 h | 48 h | 24 h | 48 h | |
| Suppurative splenitis | 5/5 | 5/5 | 5/5 | 5/5 |
| With multifocal abscesses | 5/5 | 5/5 | 4/5 | 5/5 |
| With vascular fibrinous thrombosis | 1/5 | 5/5 | 0/5 | 0/5 |
| With lymphoid atrophy or apoptosis | 0/5 | 5/5 | 1/5 | 2/5 |
| Multifocal suppurative hepatitis | 5/5 | 5/5 | 4/5 | 5/5 |
| Multifocal suppurative hepatitis with vascular thrombosis | 0/5 | 2/5 | 0/5 | 0/5 |
| Fibrinous effusion in lungs | 0/5 | 5/5 | 0/5 | 0/5 |
| Fibrinous effusion in lungs with vascular thrombosis | 0/5 | 1/5 | 0/5 | 0/5 |
a
Five mice of a given strain were infected and sacrificed at the times indicated. At least two tissue sections were examined for each of the spleen, liver, and lungs.