TABLE 2.
Pulmonary clearance patterns in mice after an aerosol challenge with M. catarrhalis mutant strain 26404lgt2 and its parental strain 26404
| Challenge straina | Bacterial recoveryb [CFU/mouse (SD range)] or reductionc (%) at:
|
||||||
|---|---|---|---|---|---|---|---|
| 0 h (recovery) | 3 h
|
6 h
|
24 h
|
||||
| Recovery | Reduction | Recovery | Reduction | Recovery | Reduction | ||
| 26404lgt2 | 34,142 (24,258-48,053) | 8,064 (5,269-12,343) | 76.4** | 4,407 (2,572-7554) | 87.1** | 152 (107-218) | 99.6 |
| 26404 | 7,945 (6,455-9,779) | 4,464 (3,778-5,276) | 43.8* | 2,505 (1,883-3,334) | 68.5* | 308 (177-534) | 96.1 |
a
Mice were challenged by aerosol with 10 ml of 26404lgt2 at 2.3 × 109 CFU/ml or 26404 at 7.5 × 108 CFU/ml.
b
Lungs were collected for bacterial counts, and the result for each time point represents the geometric mean bacterial CFU for eight mice.
c
Reduction compared with time point zero. * versus **, significant difference in bacterial reduction between 26404 and 26404lgt2 (P < 0.01).