TABLE 1.

In vitro susceptibilities of 771 isolates of Aspergillus spp. to four azole antifungal agents

Species (no. of isolates)	Antifungal agent	MIC (μg/ml)		Cumulative % of isolates inhibited at MIC (μg/ml) of:
		Range	50%/90%	0.03	0.06	0.12	0.25	0.5	1	2	4	8
A. fumigatus (553)	Itraconazole	0.12-2	0.5/1	0	0	3	17	51	93	100
	Posaconazole	0.03-2	0.25/0.5	4	17	37	79	97	99	100
	Ravuconazole	0.06-4	0.5/0.5	0	<1	3	34	92	99	>99	100
	Voriconazole	0.06-4	0.25/0.5	0	<1	13	81	98	>99	>99	100
A. flavus (76)	Itraconazole	0.12-2	0.5/1	0	0	1	20	80	99	100
	Posaconazole	0.06-2	0.25/0.5	0	1	25	75	93	97	100
	Ravuconazole	0.12-2	0.5/1	0	0	1	12	50	99	100
	Voriconazole	0.06-1	0.5/1	0	1	4	22	75	100
A. niger (59)	Itraconazole	0.5->8	2/>8	0	0	0	0	10	41	76	78	78
	Posaconazole	0.12-2	0.25/1	0	0	19	58	85	92	100
	Ravuconazole	0.25-8	2/4	0	0	0	3	14	46	88	98	100
	Voriconazole	0.12-2	0.5/1	0	0	3	12	53	97	100
A. terreus (35)	Itraconazole	0.12-1	0.5/0.5	0	0	6	34	97	100
	Posaconazole	0.06-0.5	0.25/0.25	0	9	49	94	100
	Ravuconazole	0.03-1	0.5/0.5	3	3	9	40	94	100
	Voriconazole	0.06-1	0.25/0.5	0	3	6	54	94	100
A. versicolor (24)	Itraconazole	0.12->8	1/2	0	0	4	17	33	67	96	96	96
	Posaconazole	0.06-2	0.5/1	0	8	21	46	75	92	100
	Ravuconazole	0.03-2	0.5/1	8	8	25	38	67	96	100
	Voriconazole	0.03-2	0.25/1	4	8	21	67	75	96	100
A. nidulans (5)	Itraconazole	0.5-0.5	0.5/NAc	0	0	0	0	100
	Posaconazole	0.06-0.25	0.12/NA	0	20	80	100
	Ravuconazole	0.03-2	0.12/NA	40	40	80	80	80	80	100
	Voriconazole	0.03-2	0.12/NA	40	40	80	80	80	80	100
A. sydowii (4)	Itraconazole	0.5-4	2/NA	0	0	0	0	25	25	75	100
	Posaconazole	0.25-1	0.25/NA	0	0	0	50	75	100
	Ravuconazole	0.25-2	0.25/NA	0	0	0	50	50	75	100
	Voriconazole	0.25-2	0.25/NA	0	0	0	50	75	75	100
A. calidoustus (A. ustus)a (4)	Itraconazole	0.12-2	2/NA	0	0	25	25	25	25	100
	Posaconazole	0.25-8	2/NA	0	0	0	25	25	25	50	75	100
	Ravuconazole	0.25-2	1/NA	0	0	0	25	25	50	100
	Voriconazole	0.25-4	2/NA	0	0	0	25	25	25	75	100
All Aspergillus isolatesb (771)	Itraconazole	0.12->8	0.5/2	0	0	3	17	53	88	98	98	98
	Posaconazole	0.03->8	0.25/0.5	3	13	34	76	95	98	>99	>99	>99
	Ravuconazole	0.03->8	0.5/1	1	1	4	30	80	94	99	>99	>99
	Voriconazole	0.03->8	0.25/0.5	1	1	12	67	90	98	>99	>99	>99

^aFormerly identified as A. ustus (19).

^bIn addition to the species in the table, the total includes two A. glaucus isolates, one A. oryzae isolate, and one A. niveus isolate.

^cNA, not applicable.