TABLE 2.
In vitro susceptibilities of 771 isolates of Aspergillus spp. to posaconazole, ravuconazole, and voriconazole with respect to itraconazole susceptibility
| Itraconazole category (no. of isolates) | Antifungal agent | MIC (μg/ml)
|
Cumulative % of isolates inhibited at MIC (μg/ml) of:
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Range | 50%/90% | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | ||
| Susceptible (MIC ≤ 1 μg/ml) (680) | Posaconazole | 0.03-2 | 0.25/0.5 | 3 | 15 | 37 | 81 | 97 | 99 | 100 | ||
| Ravuconazole | 0.03-4 | 0.5/1 | 1 | 1 | 5 | 34 | 85 | 99 | >99 | 100 | ||
| Voriconazole | 0.03-4 | 0.25/0.5 | 1 | 2 | 13 | 72 | 94 | >99 | >99 | 100 | ||
| Intermediate (MIC = 2 μg/ml) (74) | Posaconazole | 0.06-8 | 0.5/1 | 0 | 4 | 8 | 37 | 74 | 91 | 97 | 99 | 100 |
| Ravuconazole | 0.25-4 | 0.5/2 | 0 | 0 | 0 | 5 | 51 | 74 | 99 | 100 | ||
| Voriconazole | 0.12-4 | 0.5/2 | 0 | 0 | 3 | 38 | 68 | 89 | 97 | 100 | ||
| Resistant (MIC ≥ 4 μg/ml) (17) | Posaconazole | 0.12->8 | 0.25/1 | 0 | 0 | 29 | 77 | 82 | 94 | 94 | 94 | 94 |
| Ravuconazole | 1->8 | 2/8 | 0 | 0 | 0 | 0 | 0 | 6 | 59 | 88 | 94 | |
| Voriconazole | 0.25->8 | 1/2 | 0 | 0 | 0 | 6 | 24 | 88 | 94 | 94 | 94 | |