TABLE 2.
MIC50/MIC90 and mean MIC of C. parapsilosis, C. orthopsilosis, and C. metapsilosis isolates
| Drug |
C. parapsilosis
|
C. orthopsilosisa
|
C. metapsilosisa
|
|||
|---|---|---|---|---|---|---|
| MIC50/MIC90 | Mean MIC | MIC50/MIC90 | Mean MIC | MIC50/MIC90 | Mean MIC | |
| Fluconazole | 0.5/2 | 2.3 | 1/4 | 2.1 | 1/2 | 1.4 |
| Amphotericin B | 1/4 | 1.5 | 1/2 | 1.1 | 0.5/1 | 0.7 |
| Caspofungin | 0.5/1 | 0.4 | 0.12/0.25 | 0.2 | 0.12/0.25 | 0.2 |
| Anidulafungin | 2/2 | 1.9 | 1/2 | 1.0 | 0.5/1 | 0.6 |
| Micafungin | 1/2 | 1.1 | 0.25/0.5 | 0.4 | 0.25/0.5 | 0.4 |
a
P < 0.001 for the difference in MIC distribution compared with C. parapsilosis for all drugs tested. For fluconazole, C. orthopsilsosis and C. metapsilosis MIC distributions were higher than those of C. parapsilosis, while for amphotericin B and all the echinocandins, C. orthopsilosis and C. metapsilosis MIC distributions were lower than those of C. parapsilosis.