FIG. 6.

STAT3 target gene transcriptional expression by NS1 expression. (A) Gene expression profiling for JAK/STAT target genes was performed using RT² profiler PCR arrays 24 h after transfection of HMEC-1 cells with pcDNA-NS1, showing upregulation of genes of immune response (e.g., the IL-20 and IL2R genes) and downregulation of genes involved in virus defense (e.g., the OAS1, TYK2, and SIT1 genes). (B) The products of the most abundant regulated genes, with induction greater than twofold, are shown.