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(A) Overlay of main-chain structures of 2B4 (red) and CD2-CD58 complex (1qa9.pdb in blue). (B) Modeled three-dimensional structure of the 2B4-CD48 complex. The structure of CD48 was calculated on the basis of the known structure of CD58 (1qa9.pdb) using homology modeling. The modeled structure of CD48 was docked onto 2B4 by overlaying the CD48 and 2B4 structures on top of CD58 and CD2, respectively,in the complex.
