FIG. 2.
Nucleotide changes in human-specific HERV-K proviruses relative to HERV-KCON. (A) The numbers of changes of each type from the HERV-KCON to sequences in endogenous proviruses (listed in Materials and Methods) are plotted. For comparison of sequences flanking HERV-K60 and HERV-KI, 4,000 nucleotides immediately proximal to the 5′ and 3′ ends of the proviruses were compared for changes from chimpanzee to the orthologous human sequence. For each sequence comparison, the numbers of changes were normalized to enable direct comparison with the numbers of changes in the individual HERV-K60 and HERV-KI proviruses. (B) Graphical representation of nucleotide changes relative to HERV-KCON in the 16 human specific proviruses. Red, GG to AG; cyan, GA to AA; green, GC to AC; magenta, GT to AT; black, non-G-to-A transitions; yellow, gaps in the sequence.