FIG. 8.
Role of T lymphocytes in primary hMPV infection. Mice were treated with anti-CD4, anti-CD8, or both anti-CD4 and anti-CD8 antibodies, or with control antibodies (Ab ctrl), as described in Materials and Methods (protocol 1). Mice were either infected with hMPV or mock infected. Data are means ± SEM for four to six mice per group. Three independent experiments were performed. Asterisks indicate levels of significance (*, P < 0.05; **, P < 0.01) relative to results for hMPV-infected mice. (A) Schematic representation of the T-cell-depletion protocol. (B) Body weight loss in hMPV infection. (C) Lung peribronchial and perivascular inflammation assessed at day 7 p.i. (D) Viral replication in the lungs of BALB/c mice at day 7 p.i. by a TCID50 assay.