FIG. 5.
NS-gEnull vaccination protects against flank challenge (chall.) with HSV-1(NS), HSV-1(F), and HSV-1(17) at 105 PFU. (A) Mice were monitored for survival (P = 0.08 for strain NS, P = 0.08 for strain F, and P = 0.3 for strain 17 for comparison of the survival of immunized and mock-immunized mice). vac., vaccination. (B) Inoculation site disease (P < 0.001 for comparison of the same groups as in panel A). (C) Zosteriform disease (P < 0.001 for comparison of these groups). Three mice were challenged with strain F or 17, and four mice were challenged with strain NS. The results in panels B and C are means ± SEMs.