FIG. 7.

Levels of viral RNA in tissues of PL046-IC or E124/128-IC-infected mice. (A) Serum; (B) liver, kidneys, lungs, and spleen; (C) bone marrow, mesenteric lymph nodes (MLN), and peripheral lymph nodes (PLN); (D) stomach, large intestine, and small intestine. AG129 mice were intravenously infected with 1.5 × 10¹¹ GE of PL046-IC or E124/128-IC. The indicated tissues were harvested at 0.5, 3, 5, 7, 12, 24, and 72 h p.i., and viral RNA was quantified by real-time RT-PCR. The data are expressed as the geometric mean of DENV RNA copies relative to 18S of 3 to 10 mice per group for each time point. Asterisks denote viral RNA levels that are statistically different between PL046-IC- and E124/128-IC-infected mice (*, P < 0.05; **, P < 0.01; ***, P < 0.001).